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Home - Products - Cell Cycle/DNA Damage - DNA/RNA Synthesis - TMPyP4 tosylate

TMPyP4 tosylate

CAS No. 36951-72-1

TMPyP4 tosylate( TMP 1363 )

Catalog No. M26486 CAS No. 36951-72-1

TMPyP4 tosylate is a quadruplex-specific ligand and is a telomerase inhibitor with antitumor effects in osteosarcoma cell lines.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    TMPyP4 tosylate
  • Note
    Research use only, not for human use.
  • Brief Description
    TMPyP4 tosylate is a quadruplex-specific ligand and is a telomerase inhibitor with antitumor effects in osteosarcoma cell lines.
  • Description
    TMPyP4 tosylate is a quadruplex-specific ligand and is a telomerase inhibitor with antitumor effects in osteosarcoma cell lines.
  • In Vitro
    Cell Viability Assay Cell Line:HOS cells Concentration:50? μM Incubation Time:48 or 96 h Result:Time-dependently inhibited cell viability.Western Blot Analysis Cell Line:K562 cells Concentration:100? μM Incubation Time:24 or 48 h Result:Increased the expression of p21CIP1 protein and p57KIP2 protein.
  • In Vivo
    Animal Model:MX-1 mammary chemoadjuvant model Dosage:10 and 20 mg/kg Administration:Intraperitoneal injection (i.p.), twice weekly.Result:Inhibited tumor growth and prolonged mice survival.Animal Model:SARS-CoV-2-infected hamster Dosage:15?mg/kg or 30?mg/kg Administration:i.n., starting at 1?h prior to virus inoculation and continuing until 3 days post infection Result:Decreased the mean viral loads in the nasal wash, nasal turbinate and lung tissues.
  • Synonyms
    TMP 1363
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA/RNA Synthesis
  • Recptor
    VHL
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    36951-72-1
  • Formula Weight
    1363.6
  • Molecular Formula
    C72H66N8O12S4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 10 mg/mL (7.33 mM助)
  • SMILES
    Cc1ccc(cc1)S([O-])(=O)=O.Cc1ccc(cc1)S([O-])(=O)=O.Cc1ccc(cc1)S([O-])(=O)=O.Cc1ccc(cc1)S([O-])(=O)=O.C[n+]1ccc(cc1)-c1c2ccc(n2)c(-c2cc[n+](C)cc2)c2ccc([nH]2)c(-c2cc[n+](C)cc2)c2ccc(n2)c(-c2cc[n+](C)cc2)c2ccc1[nH]2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
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